Are COVID Patients Susceptible to other infections?
The primary outcome was the acute ischemic stroke. The Covid 19 Cohort was screened for acute ischemic stroke by using CT and MRI, which were reviewed by 2 of the attending neurologists, post their admission during their visit to the department. A third independent neurologist resolved the disagreements between the neurologists. Those who are found to be having a stroke were again studied by 2 neurologists and disagreements were resolved by a third one for the evaluation of etiological Mechanisms.
The Influenza cohort also did employ the same methods as of the Covid19 cohort and the data were retrieved from CAESER. ascertainment of ischemic stroke was based on clinical and imaging data for both cohorts. Study neurologists also tabulated data on the National Institutes of Health stroke scale at the time of stroke diagnosis. This scale ranges from 0 to 42 and higher scores indicate more severe strokes.
The trial was given consent from the review board without needing to provide informed consent as the risk of the study is low risk, and it cannot be performed otherwise.
COVID-19 and Influenza Cohorts comparison:
The 1486 influenza patients were on average, younger compared to the 1916 Covid19 patients; more frequently, women; less often had hypertension, diabetes, coronary artery disease, chronic kidney disease, or atrial fibrillation; and more frequently had hyperlipidemia**. Influenza patients also became less likely to be admitted to an ICU or undergo mechanical care Ventilation and lower sedimentation rates for D-dimers and erythrocytes.
(**Hyperlipidemia is a term used to describe high levels of fat in the blood, such as cholesterol and triglycerides.) In an unadjusted study, patients with Covid 19 were more likely than patients with influenza to experience an acute ischemic. Upon adjustment for age, sex, and race, our findings were identical.
The correlation between Covid 19 and acute ischemic stroke has persisted across several sensitivity analyses.
The correlation between COVID-19 and acute ischemic stroke has persisted across several sensitivity analyses.
The incidence of acute ischemic stroke was higher than the rate of influenza-infected patients who visited or were hospitalized. The results were consistent through multiple sensitivity analyses, including analyses adapted to the number of vascular risk factors and ICU admission status, a replacement for disease severity. They also found that Sars cov affected patients with an ischemic stroke are far more likely to die than patients with an ischemic stroke without Covid 19 infection.
There were many variations in the hypothesis as our understanding of neurological effects off Sars cov affected patients is limited as of now.
For the 214 patients in Wuhan, China, who got Covid 19, 3 percent had a stroke. Among 13 Covid 19 patients who had brain MRI in France, 23 percent had an ischemic stroke.
The proportion of Emergency department visited patients and Covid 19 hospitalizations with acute ischemic stroke were higher than that of patients who visited the Emergency Department or underwent influenza hospitalizations. These findings suggest that clinicians should be alert to symptoms and signs of acute ischemic stroke in Covid 19 patients to implement time-sensitive procedures, such as thrombolysis and thrombectomy, to reduce the long-term disability burden, if possible. At the same time, more explanation on Thrombotic pathways can produce improved strategies to avoid impaired thrombotic complications such as ischemic stroke in patients with Covid 19.
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